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濟(ji)南磐升生(sheng)(sheng)物(wu)技術(shu)(shu)有限公(gong)司(si)(si)是從事“再(zai)生(sheng)(sheng)醫(yi)(yi)(yi)學”技術(shu)(shu)領域研究(jiu)和(he)產(chan)業(ye)化的生(sheng)(sheng)物(wu)技術(shu)(shu)公(gong)司(si)(si)，山東省高新(xin)技術(shu)(shu)企業(ye)。磐升人(ren)用(yong)專(zhuan)業(ye)的心做專(zhuan)業(ye)的事，以高度(du)的責任感(gan)和(he)創新(xin)精神在“再(zai)生(sheng)(sheng)醫(yi)(yi)(yi)學”的路上頑強(qiang)拼(pin)搏，目前器(qi)官(guan)再(zai)生(sheng)(sheng)、細(xi)胞治療、細(xi)胞儲存、醫(yi)(yi)(yi)學美容、醫(yi)(yi)(yi)療器(qi)械、模(mo)式動(dong)物(wu)與(yu)檢測服(fu)務等技術(shu)(shu)達到世界領先水平。公(gong)司(si)(si)在自主創新(xin)的再(zai)生(sheng)(sheng)醫(yi)(yi)(yi)學材料平臺(tai)上，始終致力(li)于開發可(ke)替代、可(ke)修復人(ren)類組織(zhi)與(yu)器(qi)官(guan)的再(zai)生(sheng)(sheng)型醫(yi)(yi)(yi)用(yong)植入器(qi)械產(chan)品。

公(gong)司(si)(si)(si)創建于2013年(nian)(nian)，院士(shi)1人，泰山(shan)學者(zhe)2人，公(gong)司(si)(si)(si)榮獲第(di)(di)三(san)屆中(zhong)國(guo)創新創業(ye)(ye)大賽(sai)生物醫(yi)藥行業(ye)(ye)企業(ye)(ye)組第(di)(di)三(san)名并獲“優秀(xiu)企業(ye)(ye)”榮譽稱(cheng)號，2016年(nian)(nian)，公(gong)司(si)(si)(si)被(bei)增設為(wei)博(bo)士(shi)后科研工作(zuo)站和博(bo)士(shi)后實(shi)踐工作(zuo)站，中(zhong)央電視(shi)臺(tai)“創業(ye)(ye)英雄(xiong)”“走近科學”欄目先后兩次對公(gong)司(si)(si)(si)進(jin)行專訪，并受(shou)邀參(can)加國(guo)家(jia)“十(shi)二五”科技創新成(cheng)果展，被(bei)國(guo)家(jia)科技部授予榮譽證(zheng)書。2018年(nian)(nian)評為(wei)“最有(you)投資(zi)價(jia)值的(de)(de)留學人員企業(ye)(ye)”。2019年(nian)(nian)公(gong)司(si)(si)(si)被(bei)評為(wei)“山(shan)東(dong)省優秀(xiu)企業(ye)(ye)”，“山(shan)東(dong)省組織(zhi)工程與再(zai)生醫(yi)學工程實(shi)驗(yan)室”，并成(cheng)立“盧世璧(bi)院士(shi)工作(zuo)站”。作(zuo)為(wei)世界上首個用細胞(bao)再(zai)生出具有(you)功能的(de)(de)器官組織(zhi)的(de)(de)企業(ye)(ye)，公(gong)司(si)(si)(si)不僅完成(cheng)多(duo)項一類、二類、三(san)類醫(yi)療器械的(de)(de)成(cheng)果審批及臨床應用，并參(can)與了(le)四項國(guo)家(jia)標準的(de)(de)制定。2020年(nian)(nian)，公(gong)司(si)(si)(si)投資(zi)2.8億建設了(le)七萬平方米(mi)的(de)(de)磐升生物產業(ye)(ye)園，為(wei)公(gong)司(si)(si)(si)的(de)(de)產品轉化(hua)打下(xia)了(le)良(liang)好的(de)(de)基礎，

磐(pan)升(sheng)生(sheng)物有限(xian)公司目(mu)前擁(yong)有一(yi)(yi)套成熟穩定的(de)(de)(de)(de)技術(shu)可從皮(pi)(pi)(pi)膚(fu)組織(zhi)中(zhong)分離出(chu)干細胞，在體外（培養皿中(zhong)）培養和(he)擴增皮(pi)(pi)(pi)膚(fu)干細胞，并能將擴增的(de)(de)(de)(de)細胞移植(zhi)到創 傷處再生(sheng)出(chu)新(xin)的(de)(de)(de)(de)完整(zheng)皮(pi)(pi)(pi)膚(fu)。再生(sheng)出(chu)的(de)(de)(de)(de)皮(pi)(pi)(pi)膚(fu)帶有毛發(fa)、汗腺、血管、神經 等附屬(shu)器官，并擁(yong)有正常皮(pi)(pi)(pi)膚(fu)的(de)(de)(de)(de)功能。該技術(shu)可用(yong)于白癜風(feng)、色素痣、痤瘡等色素性皮(pi)(pi)(pi)膚(fu)疾病的(de)(de)(de)(de)修(xiu)復及(ji)治療，以及(ji)疤痕、刺青等問題(ti)皮(pi)(pi)(pi)膚(fu)的(de)(de)(de)(de)修(xiu)復。為(wei)臨床提供了一(yi)(yi)種(zhong)全新(xin)的(de)(de)(de)(de)、有效的(de)(de)(de)(de)臨床解決(jue)方案。該技術(shu)達到世界領先水平。

2019年濟(ji)南(nan)(nan)市(shi)科(ke)技局(ju)、濟(ji)南(nan)(nan)市(shi)發(fa)(fa)改(gai)委、濟(ji)南(nan)(nan)市(shi)食品(pin)藥品(pin)管(guan)理局(ju)和(he)(he)(he)濟(ji)南(nan)(nan)市(shi)衛(wei)生(sheng)(sheng)(sheng)(sheng)局(ju)聯合發(fa)(fa)文支持企業(ye)籌備建設組織細(xi)胞(bao)(bao)(bao)(bao)(bao)資(zi)源庫(ku)，為(wei)組織工(gong)(gong)程的(de)(de)(de)產品(pin)產業(ye)化提供了合法的(de)(de)(de)種子(zi)來源。磐升生(sheng)(sheng)(sheng)(sheng)物(wu)(wu)(wu)自主知識產權的(de)(de)(de)產品(pin)工(gong)(gong)程化技術(shu)(shu)和(he)(he)(he)工(gong)(gong)藝(yi)流程，開發(fa)(fa)帶活(huo)(huo)性細(xi)胞(bao)(bao)(bao)(bao)(bao)的(de)(de)(de)組織工(gong)(gong)程產品(pin)，包括人(ren)工(gong)(gong)皮(pi)膚，人(ren)工(gong)(gong)軟(ruan)(ruan)骨和(he)(he)(he)人(ren)工(gong)(gong)角膜(mo)等一系(xi)列的(de)(de)(de)再生(sheng)(sheng)(sheng)(sheng)型(xing)(xing)植(zhi)入性醫(yi)療器械新型(xing)(xing)產品(pin)，并建立(li)相應的(de)(de)(de)技術(shu)(shu)標(biao)準體系(xi)。目前磐升生(sheng)(sheng)(sheng)(sheng)物(wu)(wu)(wu)利(li)用(yong)(yong)真皮(pi)細(xi)胞(bao)(bao)(bao)(bao)(bao)和(he)(he)(he)表(biao)皮(pi)細(xi)胞(bao)(bao)(bao)(bao)(bao)體外(wai)共培養(yang)，生(sheng)(sheng)(sheng)(sheng)產出帶活(huo)(huo)性細(xi)胞(bao)(bao)(bao)(bao)(bao)的(de)(de)(de)人(ren)造全層(ceng)皮(pi)。人(ren)工(gong)(gong)皮(pi)膚作(zuo)(zuo)為(wei)三(san)類(lei)醫(yi)療器械用(yong)(yong)臨床真皮(pi)層(ceng)缺損(sun)、燒燙傷(shang)創(chuang)面(mian)的(de)(de)(de)保(bao)護愈(yu)合和(he)(he)(he)糖尿病(bing)足的(de)(de)(de)愈(yu)合治療等，并可以作(zuo)(zuo)為(wei)國家戰略儲(chu)備物(wu)(wu)(wu)資(zi)和(he)(he)(he)民生(sheng)(sheng)(sheng)(sheng)保(bao)障產品(pin)進行儲(chu)備。和(he)(he)(he)盧世璧院(yuan)士團隊，成立(li)院(yuan)士工(gong)(gong)作(zuo)(zuo)站，攻克第四代軟(ruan)(ruan)骨技術(shu)(shu)和(he)(he)(he)軟(ruan)(ruan)骨修復材(cai)料(liao)。另外(wai)集中(zhong)生(sheng)(sheng)(sheng)(sheng)物(wu)(wu)(wu)材(cai)料(liao)學、細(xi)胞(bao)(bao)(bao)(bao)(bao)生(sheng)(sheng)(sheng)(sheng)物(wu)(wu)(wu)學、分子(zi)生(sheng)(sheng)(sheng)(sheng)物(wu)(wu)(wu)學及(ji)臨床醫(yi)學專家聯合攻關，利(li)用(yong)(yong)自身細(xi)胞(bao)(bao)(bao)(bao)(bao)移植(zhi)再生(sheng)(sheng)(sheng)(sheng)技術(shu)(shu)開發(fa)(fa)帶活(huo)(huo)性細(xi)胞(bao)(bao)(bao)(bao)(bao)的(de)(de)(de)人(ren)工(gong)(gong)角膜(mo)。

磐升生(sheng)(sheng)(sheng)物(wu)致力于(yu)建(jian)(jian)立國(guo)際領(ling)先的(de)(de)(de)(de)體外替代檢(jian)測(ce)(ce)平(ping)(ping)臺(tai)，已建(jian)(jian)立基于(yu)各類細胞(bao)和3D重(zhong)組(zu)皮(pi)膚(fu)模(mo)型(xing)(xing)的(de)(de)(de)(de)體外安全(quan)性與功(gong)效性檢(jian)測(ce)(ce)平(ping)(ping)臺(tai)，該(gai)試(shi)(shi)劑盒(he)能(neng)夠(gou)比動物(wu)檢(jian)測(ce)(ce)方(fang)法(fa)更(geng)精確地預測(ce)(ce)化妝品(pin)(pin)及藥品(pin)(pin)產品(pin)(pin)對皮(pi)膚(fu)的(de)(de)(de)(de)作用，該(gai)產品(pin)(pin)正在(zai)與國(guo)家食藥總局和山東省食品(pin)(pin)藥品(pin)(pin)監督管理局制定(ding)了國(guo)家醫療(liao)器械檢(jian)測(ce)(ce)替代方(fang)法(fa)國(guo)家標(biao)準。另外開發(fa)了化妝品(pin)(pin)檢(jian)測(ce)(ce)試(shi)(shi)劑盒(he)，將分離(li)的(de)(de)(de)(de)東亞人(ren)(ren)種的(de)(de)(de)(de)人(ren)(ren)表皮(pi)細胞(bao)接種在(zai)特定(ding)的(de)(de)(de)(de)生(sheng)(sheng)(sheng)物(wu)材料上(shang)進(jin)行培(pei)養(yang),形(xing)成具有三維(wei)結構的(de)(de)(de)(de)人(ren)(ren)表皮(pi)樣皮(pi)膚(fu)模(mo)型(xing)(xing)。體外替代檢(jian)測(ce)(ce)的(de)(de)(de)(de)基本原理是利用離(li)體細胞(bao)或組(zu)織(zhi)模(mo)型(xing)(xing)，模(mo)擬正常的(de)(de)(de)(de)人(ren)(ren)體生(sheng)(sheng)(sheng)理功(gong)能(neng)與暴露條件，檢(jian)測(ce)(ce)受試(shi)(shi)物(wu)質對分子、細胞(bao)以(yi)及組(zu)織(zhi)等不同水平(ping)(ping)的(de)(de)(de)(de)生(sheng)(sheng)(sheng)物(wu)靶標(biao)的(de)(de)(de)(de)影(ying)響，以(yi)此(ci)達到(dao)判定(ding)受試(shi)(shi)物(wu)質安全(quan)性與功(gong)效性的(de)(de)(de)(de)目的(de)(de)(de)(de)。基于(yu)上(shang)述(shu)原理及離(li)體模(mo)型(xing)(xing)的(de)(de)(de)(de)優(you)勢(shi)，體外測(ce)(ce)試(shi)(shi)可以(yi)得到(dao)某些(xie)在(zai)動物(wu)實驗(yan)上(shang)無(wu)法(fa)檢(jian)測(ce)(ce)的(de)(de)(de)(de)指標(biao)變(bian)化。

磐升生物(wu)(wu)(wu)(wu)(wu)(wu)利用(yong)皮膚細(xi)胞(bao)生長因子，采用(yong)脂質體包裹技術，開發了(le)在面部注射(she)用(yong)的(de)(de)外泌體，毛囊修復(fu)液，疤痕凝膠等醫(yi)美方面的(de)(de)產(chan)(chan)品。同時開發了(le)皮膚填(tian)(tian)(tian)充(chong)劑(ji)第(di)三(san)代產(chan)(chan)品為(wei)微(wei)球(qiu)填(tian)(tian)(tian)充(chong)劑(ji)。微(wei)球(qiu)皮膚填(tian)(tian)(tian)充(chong)劑(ji)的(de)(de)聚(ju)(ju)(ju)合(he)物(wu)(wu)(wu)(wu)(wu)(wu)材料(liao)(liao)包括(kuo)：聚(ju)(ju)(ju)左旋乳酸(suan)（PLLA），聚(ju)(ju)(ju)己內酯(PCL)，聚(ju)(ju)(ju)甲基丙烯酸(suan)酯(PMMA)，聚(ju)(ju)(ju)乙烯醇(chun)(PVA)等。其中PLLA，PCL為(wei)聚(ju)(ju)(ju)酯類生物(wu)(wu)(wu)(wu)(wu)(wu)材料(liao)(liao)，具有生物(wu)(wu)(wu)(wu)(wu)(wu)相容性(xing)好，可(ke)生物(wu)(wu)(wu)(wu)(wu)(wu)降解，無免(mian)疫(yi)(yi)原性(xing)，維持(chi)時間長（可(ke)達(da)2年(nian)）等優(you)點，日益受到(dao)醫(yi)學美容行(xing)業(ye)的(de)(de)重(zhong)視。注射(she)用(yong)PLLA微(wei)球(qiu)，非免(mian)疫(yi)(yi)原性(xing)、人工(gong)合(he)成、生物(wu)(wu)(wu)(wu)(wu)(wu)相容性(xing)好，由a-含(han)氧酸(suan)聚(ju)(ju)(ju)合(he)物(wu)(wu)(wu)(wu)(wu)(wu)懸浮在羧基纖維素鈉(na)鹽和甘(gan)露醇(chun)溶液中。PLLA既往被用(yong)在整形外科和頜(he)面外科，用(yong)來做可(ke)吸收縫合(he)線和螺釘、骨內填(tian)(tian)(tian)充(chong)和軟(ruan)組(zu)織(zhi)填(tian)(tian)(tian)充(chong)，在牙周手術中用(yong)來做新(xin)生組(zu)織(zhi)爬行(xing)的(de)(de)引導膜。可(ke)注射(she)的(de)(de)聚(ju)(ju)(ju)L-乳酸(suan)（PLLA）已成為(wei)恢(hui)復(fu)年(nian)輕外觀(guan)到(dao)老(lao)化(hua)面部的(de)(de)越來越多(duo)的(de)(de)選擇。這種微(wei)創手術涉及(ji)在不對其進行(xing)單獨皺紋治療的(de)(de)情(qing)況下在其應用(yong)區(qu)域內產(chan)(chan)生持(chi)久的(de)(de)作(zuo)用(yong)，PLLA的(de)(de)作(zuo)用(yong)機制似(si)乎主要取(qu)決于宿(su)主反應和PLLA微(wei)球(qiu)的(de)(de)緩(huan)慢降解。

細(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)療(liao)法是(shi)一(yi)(yi)種將活細(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)注射到(dao)病(bing)人體內以治(zhi)(zhi)療(liao)某些(xie)疾病(bing)的(de)(de)(de)(de)(de)方(fang)法，細(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)療(liao)法被認為最具(ju)(ju)有(you)潛力(li)解決當前未得到(dao)滿足(zu)的(de)(de)(de)(de)(de)臨床(chuang)(chuang)需求(qiu)，全(quan)(quan)球已經有(you)大約20多種細(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)療(liao)法獲得批準(zhun)，同時500多種基于細(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)的(de)(de)(de)(de)(de)治(zhi)(zhi)療(liao)方(fang)案處在臨床(chuang)(chuang)開發(fa)(fa)的(de)(de)(de)(de)(de)不(bu)同階段中。隨著細(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)治(zhi)(zhi)療(liao)候(hou)選方(fang)案的(de)(de)(de)(de)(de)持(chi)續(xu)增(zeng)加(jia)(jia)，以及臨床(chuang)(chuang)開發(fa)(fa)的(de)(de)(de)(de)(de)快速發(fa)(fa)展(zhan)，整個(ge)行(xing)業(ye)對(dui)細(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)制(zhi)造相關設備(bei)平(ping)臺(tai)(tai)和(he)(he)服務的(de)(de)(de)(de)(de)需求(qiu)不(bu)斷增(zeng)加(jia)(jia)。當前，細(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)制(zhi)造已經形成(cheng)(cheng)了龐(pang)大的(de)(de)(de)(de)(de)市場。細(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)治(zhi)(zhi)療(liao)可分(fen)為免(mian)疫細(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)（懸(xuan)浮細(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)居(ju)多）和(he)(he)干(gan)細(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)（貼壁細(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)居(ju)多）治(zhi)(zhi)療(liao)，全(quan)(quan)球大部分(fen)廠(chang)家(jia)將產(chan)(chan)(chan)品(pin)研發(fa)(fa)重點(dian)放在了懸(xuan)浮細(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)培(pei)養(yang)自(zi)(zi)(zi)動(dong)(dong)(dong)(dong)(dong)(dong)(dong)(dong)(dong)化(hua)(hua)上(shang)，其原(yuan)因包括了應(ying)用(yong)(yong)(yong)場景較為集中，設備(bei)開發(fa)(fa)相對(dui)簡單(dan)，已得到(dao)批準(zhun)的(de)(de)(de)(de)(de)臨床(chuang)(chuang)種類(lei)相對(dui)較多等等。目前，針對(dui)貼壁細(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)培(pei)養(yang)的(de)(de)(de)(de)(de)完(wan)整的(de)(de)(de)(de)(de)全(quan)(quan)自(zi)(zi)(zi)動(dong)(dong)(dong)(dong)(dong)(dong)(dong)(dong)(dong)化(hua)(hua)系統(tong)寥寥無(wu)幾。磐升生(sheng)(sheng)(sheng)物自(zi)(zi)(zi)主開發(fa)(fa)了國(guo)(guo)內首臺(tai)(tai)貼壁細(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)培(pei)養(yang)和(he)(he)傳(chuan)(chuan)(chuan)代(dai)設計(ji)的(de)(de)(de)(de)(de)全(quan)(quan)自(zi)(zi)(zi)動(dong)(dong)(dong)(dong)(dong)(dong)(dong)(dong)(dong)化(hua)(hua)系統(tong)。通(tong)常細(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)培(pei)養(yang)，擴(kuo)增(zeng)和(he)(he)傳(chuan)(chuan)(chuan)代(dai)是(shi)生(sheng)(sheng)(sheng)物醫藥行(xing)業(ye)必須的(de)(de)(de)(de)(de)環節，也(ye)是(shi)干(gan)細(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)和(he)(he)免(mian)疫細(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)臨床(chuang)(chuang)應(ying)用(yong)(yong)(yong)關鍵技(ji)(ji)術(shu)(shu)(shu)的(de)(de)(de)(de)(de)源頭，細(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)培(pei)養(yang)擴(kuo)增(zeng)傳(chuan)(chuan)(chuan)代(dai)自(zi)(zi)(zi)動(dong)(dong)(dong)(dong)(dong)(dong)(dong)(dong)(dong)化(hua)(hua)技(ji)(ji)術(shu)(shu)(shu)有(you)著巨大的(de)(de)(de)(de)(de)市場需求(qiu)。從第(di)一(yi)(yi)代(dai)的(de)(de)(de)(de)(de)細(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)因子、多肽類(lei)藥物，第(di)二代(dai)的(de)(de)(de)(de)(de)融合蛋白、抗(kang)體藥物，到(dao)第(di)三(san)代(dai)的(de)(de)(de)(de)(de)CAR-T細(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)治(zhi)(zhi)療(liao)、干(gan)細(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)技(ji)(ji)術(shu)(shu)(shu)，無(wu)論(lun)其研發(fa)(fa)還是(shi)生(sheng)(sheng)(sheng)產(chan)(chan)(chan)，都(dou)需要(yao)用(yong)(yong)(yong)到(dao)細(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)培(pei)養(yang)擴(kuo)增(zeng)和(he)(he)傳(chuan)(chuan)(chuan)代(dai)工(gong)藝，現有(you)的(de)(de)(de)(de)(de)手動(dong)(dong)(dong)(dong)(dong)(dong)(dong)(dong)(dong)操作(zuo)(zuo)在整個(ge)細(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)培(pei)養(yang)過程(cheng)，成(cheng)(cheng)本(ben)很(hen)(hen)高，細(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)受污染的(de)(de)(de)(de)(de)風險很(hen)(hen)高，現在國(guo)(guo)家(jia)尚沒有(you)此(ci)類(lei)細(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)培(pei)養(yang)標準(zhun)；全(quan)(quan)自(zi)(zi)(zi)動(dong)(dong)(dong)(dong)(dong)(dong)(dong)(dong)(dong)化(hua)(hua)細(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)培(pei)養(yang)將會(hui)帶來很(hen)(hen)多質(zhi)的(de)(de)(de)(de)(de)改進，而(er)且可以以此(ci)流程(cheng)為標準(zhun)申請國(guo)(guo)家(jia)的(de)(de)(de)(de)(de)行(xing)業(ye)新標準(zhun)。磐升生(sheng)(sheng)(sheng)物提出一(yi)(yi)個(ge)獨立(li)的(de)(de)(de)(de)(de)自(zi)(zi)(zi)動(dong)(dong)(dong)(dong)(dong)(dong)(dong)(dong)(dong)化(hua)(hua)細(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)培(pei)養(yang)系統(tong)方(fang)案，具(ju)(ju)有(you)所有(you)穩定細(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)生(sheng)(sheng)(sheng)長和(he)(he)培(pei)養(yang)所需的(de)(de)(de)(de)(de)功(gong)能，從自(zi)(zi)(zi)動(dong)(dong)(dong)(dong)(dong)(dong)(dong)(dong)(dong)移液器(qi)，真空抽吸，搖(yao)動(dong)(dong)(dong)(dong)(dong)(dong)(dong)(dong)(dong)（搖(yao)擺），介(jie)質(zhi)加(jia)(jia)熱和(he)(he)冷卻(que)，孵化(hua)(hua)到(dao)自(zi)(zi)(zi)動(dong)(dong)(dong)(dong)(dong)(dong)(dong)(dong)(dong)離心(xin)機，系統(tong)將用(yong)(yong)(yong)自(zi)(zi)(zi)動(dong)(dong)(dong)(dong)(dong)(dong)(dong)(dong)(dong)化(hua)(hua)完(wan)全(quan)(quan)替代(dai)手動(dong)(dong)(dong)(dong)(dong)(dong)(dong)(dong)(dong)和(he)(he)重復(fu)的(de)(de)(de)(de)(de)任務。其核心(xin)技(ji)(ji)術(shu)(shu)(shu)包括核心(xin)技(ji)(ji)術(shu)(shu)(shu)機器(qi)視覺(jue)實時監控(kong)(kong)(kong)細(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)生(sheng)(sheng)(sheng)長程(cheng)度(du)；圖(tu)像處理和(he)(he)云(yun)平(ping)臺(tai)(tai)配(pei)合精確(que)完(wan)成(cheng)(cheng)細(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)計(ji)數(shu)；氣動(dong)(dong)(dong)(dong)(dong)(dong)(dong)(dong)(dong)柔性機器(qi)人驅動(dong)(dong)(dong)(dong)(dong)(dong)(dong)(dong)(dong)，有(you)效解決電驅動(dong)(dong)(dong)(dong)(dong)(dong)(dong)(dong)(dong)對(dui)細(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)環境溫度(du)的(de)(de)(de)(de)(de)影(ying)響和(he)(he)普(pu)通(tong)氣動(dong)(dong)(dong)(dong)(dong)(dong)(dong)(dong)(dong)平(ping)臺(tai)(tai)低(di)精度(du)的(de)(de)(de)(de)(de)問題；顯(xian)微(wei)高精度(du)位移控(kong)(kong)(kong)制(zhi)完(wan)成(cheng)(cheng)對(dui)個(ge)別細(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)的(de)(de)(de)(de)(de)分(fen)析等。自(zi)(zi)(zi)動(dong)(dong)(dong)(dong)(dong)(dong)(dong)(dong)(dong)化(hua)(hua)培(pei)養(yang)和(he)(he)傳(chuan)(chuan)(chuan)代(dai)自(zi)(zi)(zi)動(dong)(dong)(dong)(dong)(dong)(dong)(dong)(dong)(dong)化(hua)(hua)系統(tong)是(shi)整個(ge)細(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)生(sheng)(sheng)(sheng)產(chan)(chan)(chan)自(zi)(zi)(zi)動(dong)(dong)(dong)(dong)(dong)(dong)(dong)(dong)(dong)化(hua)(hua)的(de)(de)(de)(de)(de)一(yi)(yi)部分(fen)，也(ye)是(shi)最迫切(qie)需要(yao)的(de)(de)(de)(de)(de)部分(fen)。 在其基礎上(shang)，細(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)生(sheng)(sheng)(sheng)產(chan)(chan)(chan)自(zi)(zi)(zi)動(dong)(dong)(dong)(dong)(dong)(dong)(dong)(dong)(dong)化(hua)(hua)可以擴(kuo)展(zhan)到(dao)組(zu)織處理，原(yuan)代(dai)細(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)提取，試劑配(pei)備(bei)，細(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)冷藏等等。 我(wo)國(guo)(guo)《細(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)治(zhi)(zhi)療(liao)產(chan)(chan)(chan)品(pin)研究(jiu)與評(ping)價技(ji)(ji)術(shu)(shu)(shu)指(zhi)導原(yuan)則(ze)（試行(xing)）》表示，細(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)治(zhi)(zhi)療(liao)產(chan)(chan)(chan)品(pin)的(de)(de)(de)(de)(de)生(sheng)(sheng)(sheng)產(chan)(chan)(chan)過程(cheng)應(ying)遵從《藥品(pin)生(sheng)(sheng)(sheng)產(chan)(chan)(chan)質(zhi)量管理規(gui)范》的(de)(de)(de)(de)(de)基本(ben)規(gui)范和(he)(he)相關原(yuan)則(ze)，研究(jiu)者需建立(li)細(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)治(zhi)(zhi)療(liao)產(chan)(chan)(chan)品(pin)的(de)(de)(de)(de)(de)質(zhi)量控(kong)(kong)(kong)制(zhi)策略，建議確(que)證性臨床(chuang)(chuang)試驗用(yong)(yong)(yong)樣品(pin)的(de)(de)(de)(de)(de)質(zhi)量控(kong)(kong)(kong)制(zhi)與商業(ye)化(hua)(hua)生(sheng)(sheng)(sheng)產(chan)(chan)(chan)時的(de)(de)(de)(de)(de)質(zhi)控(kong)(kong)(kong)要(yao)求(qiu)保(bao)持(chi)一(yi)(yi)致。研究(jiu)者應(ying)不(bu)斷優化(hua)(hua)制(zhi)備(bei)工(gong)藝，減少物理、化(hua)(hua)學或(huo)生(sheng)(sheng)(sheng)物學作(zuo)(zuo)用(yong)(yong)(yong)對(dui)細(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)胞(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)(bao)的(de)(de)(de)(de)(de)特性產(chan)(chan)(chan)生(sheng)(sheng)(sheng)非(fei)預(yu)期的(de)(de)(de)(de)(de)影(ying)響，盡量達到(dao)自(zi)(zi)(zi)動(dong)(dong)(dong)(dong)(dong)(dong)(dong)(dong)(dong)化(hua)(hua)、全(quan)(quan)封閉的(de)(de)(de)(de)(de)生(sheng)(sheng)(sheng)產(chan)(chan)(chan)。

磐升人(ren)用專(zhuan)業的(de)心做專(zhuan)業的(de)事，以高度的(de)責任感和創新精(jing)神在“再(zai)生醫學”的(de)路上頑強拼搏(bo)。